Female Fertility Timeline: How It Declines with Age and Ways to Boost Reproductive Health

Female Fertility Timeline: How It Declines with Age and Ways to Boost Reproductive Health

As women enter their thirties, many start considering when is the right time to start a family. This can often be a period filled with questions about fertility, timing, and how age affects the chances of getting pregnant. Understanding how your fertility changes over time—and how to optimise it—can empower you to make informed decisions about your reproductive health.


The Biological Clock: Fertility and Age


A woman is born with all the eggs she will ever have, and this number gradually declines throughout her life 1 . By the time puberty hits, the average woman has around 300,000 to 400,000 eggs. But these numbers aren’t just shrinking with each cycle; the quality of the remaining eggs also diminishes as time passes. This process is known as ‘ovarian aging’ 2 .


- In your 20s: Fertility is at its peak. During this time, the chances of getting pregnant naturally per cycle are about 25-30%.

- In your early 30s: Fertility remains relatively high, though it begins to decline slowly. Women in their early 30s have a 20-25% chance of conceiving per cycle.

- At age 35 and beyond, Fertility declines more significantly. By age 35, the chance of getting pregnant naturally drops to about 15-20% per cycle. This is also when the risk of miscarriage and chromosomal abnormalities in eggs increases.

- By age 40:The likelihood of pregnancy drops sharply to around 5% per cycle. 


The declining egg count and quality are critical factors in this age-related decline in fertility 1 . However, it’s important to note that every woman is unique, and some may experience different patterns of fertility based on lifestyle, genetics, and overall health.


Understanding Ovarian Aging


Ovarian aging refers to the natural decline in the quantity and quality of a woman’s eggs as she ages. This aging process affects both the number of eggs (ovarian reserve) and the health of the eggs that remain. Not only are there fewer eggs as a woman gets older, but the eggs are also more likely to have chromosomal abnormalities, which can lead to infertility, miscarriage, or birth defects 3 .


Testing ovarian reserve through hormone measurements, such as ‘Anti-Müllerian Hormone (AMH)’ or ‘Follicle Stimulating Hormone (FSH)’ levels, can provide some insight into your fertility potential 3 . Please note that these tests look at the quantity and NOT the quality of the eggs. 


How to Boost Fertility in Your Thirties


Though fertility naturally declines with age, there are steps you can take to enhance your reproductive health. If you are a woman in your thirties planning to conceive in the next year, making lifestyle adjustments and prioritising your fertility now can have a positive impact. Here are some evidence-based strategies that may improve your chances:


  1. Maintain a Healthy Diet and Weight 

   A diet rich in whole foods, fruits, vegetables, and lean proteins is crucial for reproductive health. Some studies suggest that the ‘Mediterranean diet’, which is high in antioxidants and healthy fats, may improve fertility outcomes 4 . Being underweight or overweight can disrupt hormonal balance, affecting ovulation and fertility. Maintaining a healthy weight can support your chances of conception.


  1. Exercise in Moderation

   Regular, moderate exercise helps maintain a healthy body and hormonal balance, but avoiding overexertion is essential. Intense training, especially endurance sports, can sometimes disrupt ovulation and lead to fertility issues 5 . Aim for moderate activities like brisk walking, yoga, or swimming.


  1. Manage Stress Levels

   Chronic stress can interfere with your reproductive hormones and ovulation 6 . Finding healthy ways to cope with stress—whether through mindfulness, meditation, or therapy—can support overall fertility.


  1. Quit Smoking and Limit Alcohol 

   Smoking accelerates ovarian aging and depletes the egg reserve faster. It’s one of the most significant lifestyle factors that negatively affect fertility 7 . Likewise, excessive alcohol consumption has been linked to decreased fertility and irregular ovulation 8 . If you’re trying to conceive, it's best to limit alcohol intake or avoid it altogether.


  1. Boost your Antioxidant Intake  

   As women age, oxidative stress can contribute to egg aging. Antioxidants help neutralize free radicals and protect egg quality 9 . Studies have shown that supplements like CoQ10 improve egg quality in women, especially those over 35 10 .


  1. Consider a good quality Prenatal Vitamin  

   Prenatal vitamins prepare your body for pregnancy and can reduce the risk of birth defects. Taking a high-quality prenatal vitamin at least three months before trying to conceive is recommended.


  1. Consult a Fertility Specialist Early

   If you’ve been trying to conceive for six months or more without success, or if you're over 35 and planning to try soon, it might be a good idea to see a fertility specialist. Early intervention can help address any underlying issues that may impact fertility, and it’s a proactive step to understanding your reproductive health.


Taking Charge of Your Reproductive Health


For women in their thirties, time is a crucial factor when it comes to fertility, but taking care of your reproductive health can help maximise your chances of conception. By adopting a healthy lifestyle, incorporating fertility-boosting strategies like antioxidants, and being proactive about your fertility timeline, you can optimise your chances of getting pregnant naturally. It's never too early to start focusing on your fertility, so take action now and prioritise your reproductive health.


If you are planning to conceive within the next year, now is the time to start preparing. Small changes today can make a big difference for your fertility tomorrow.

 

References

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2. Wang X, Wang L, Xiang W. Mechanisms of ovarian aging in women: a review. J Ovarian Res. 2023 Apr 6;16(1):67. doi: 10.1186/s13048-023-01151-z. PMID: 37024976; PMCID: PMC10080932.

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5. Mussawar M, Balsom AA, Totosy de Zepetnek JO, Gordon JL. The effect of physical activity on fertility: a mini-review. F S Rep. 2023 Apr 14;4(2):150-158. doi: 10.1016/j.xfre.2023.04.005. PMID: 37398617; PMCID: PMC10310950.

6. Vigil P, Lyon C, Flores B, Rioseco H, Serrano F. Ovulation, a sign of health. Linacre Q. 2017 Nov;84(4):343-355. doi: 10.1080/00243639.2017.1394053. Epub 2017 Nov 27. PMID: 29255329; PMCID: PMC5730019.

7. Dhage VD, Nagtode N, Kumar D, Bhagat AK. A Narrative Review on the Impact of Smoking on Female Fertility. Cureus. 2024 Apr 16;16(4):e58389. doi: 10.7759/cureus.58389. PMID: 38756292; PMCID: PMC11097250.

8. de Angelis C, Nardone A, Garifalos F, Pivonello C, Sansone A, Conforti A, Di Dato C, Sirico F, Alviggi C, Isidori A, Colao A, Pivonello R. Smoke, alcohol and drug addiction and female fertility. Reprod Biol Endocrinol. 2020 Mar 12;18(1):21. doi: 10.1186/s12958-020-0567-7. PMID: 32164734; PMCID: PMC7069005.

9. Ra K, Park SC, Lee BC. Female Reproductive Aging and Oxidative Stress: Mesenchymal Stem Cell Conditioned Medium as a Promising Antioxidant. Int J Mol Sci. 2023 Mar 6;24(5):5053. doi: 10.3390/ijms24055053. PMID: 36902477; PMCID: PMC10002910.

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