NAD+ and Ovarian Aging: A Promising Update

NAD+ and Ovarian Aging: A Promising Update

The role of NAD+ (Nicotinamide Adenine Dinucleotide) in addressing age-related fertility issues in women is an exciting and promising area of research. Understanding and harnessing the potential of NAD+ could pave the way for groundbreaking fertility treatments and improved reproductive health for women.

Understanding Ovarian Aging

As women age, their fertility naturally declines. This is due to the steady decrease in both the quantity and quality of ovarian reserves. Women are born with a finite number of follicles, which gradually diminish from birth through menopause. By the late 30s and 40s, the number and quality of oocytes (eggs) drop significantly, leading to reduced fertility, irregular menstrual cycles, and eventually, menopause.


The Vital Role of NAD+

NAD+ is a crucial coenzyme involved in many cellular processes, including energy production, DNA repair, and cell signalling. As women age, NAD+ levels decline, which affects cellular function and contributes to the aging process. This decline in NAD+ levels impacts ovarian aging and overall fertility.


Emerging Research and Hopeful Findings

Recent research has highlighted the role of NAD+ in combating various age-related conditions such as cancer, Alzheimer’s, and cardiovascular diseases. Interestingly, maintaining NAD+ levels also shows promise in improving oocyte quality and overall fertility. Although this area of study is still developing, the potential benefits are exciting. 1


Boosting NAD+ Levels

Supplementing NAD+ precursors, such as Nicotinamide Riboside Chloride (NRC) and Nicotinamide Mononucleotide (NMN), has shown encouraging results in animal studies. These supplements have been found to increase ovarian reserves and improve the quality of oocytes, potentially restoring fertility in older females. Note:  NMN is not approved for use in supplements in Australia. 


A Bright Future for Women's Reproductive Health

Understanding the intricate relationship between NAD+ and ovarian aging opens new avenues for enhancing female reproductive health. By exploring NAD+ supplementation and its potential benefits, we can look forward to improved fertility treatments and better reproductive health for women.


The ongoing research into NAD+ offers hope and optimism. As science progresses, women may soon have access to innovative treatments that help maintain their fertility and overall well-being, regardless of age.



1. Ahmed M, Riaz U, Lv H, Yang L. A Molecular Perspective and Role of NAD+ in Ovarian Aging. International Journal of Molecular Sciences. 2024; 25(9):4680.